Abstract
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in many cases, high levels of selectivity versus other PDE isoforms.
MeSH terms
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Models, Molecular
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Molecular Structure
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Phosphodiesterase Inhibitors / chemistry
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Phosphodiesterase Inhibitors / pharmacology*
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Phosphoric Diester Hydrolases / drug effects*
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Xanthines / chemistry
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Xanthines / pharmacology*
Substances
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Phosphodiesterase Inhibitors
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Xanthines
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Phosphoric Diester Hydrolases